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Hypercholosterolemia

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Published in: Zoology
4,322 Views

This presentation is about the Pedigree Analysis of Hypercholesterolemia.

Sancy H / Kochi

5 years of teaching experience

Qualification: M.Sc.(Zoology)

Teaches: All Subjects, Science, Biology, Chemistry, Physics, Zoology, Social Studies, Anatomy, Bio Chemistry, Botany, Microbiology, Physiology, Psychology, English

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  1. OF HYPERCHOLESTEROLEmA AND ITS POPULATION IN WKSTKOCHI
  2. OBJECTIVE The aim of this project is to study the cause, effects and pattern of inheritance of hypercholesterolemia among the mixed population of pallurity.
  3. RODUCTION Hypercholesterolemia high or cholesterol occurs when there is too much cholesterol. Cholesterol is a soft, waxy, and fat like substance that is a natural component of all the cells of the body. Familial Hypercholesterolemia is an autosomal dominant disease. It is caused due to mutation in the chromosome 19. High cholesterol can also be associated with other diseases such as diabetes. High cholesterol is more
  4. SYMPTOMS Generally High blood cholesterol levels can be asymptomatic, some of the signs and symptoms may include: Family history of the disorder Family history of heart attacks at an earlier age High HDL cholesterol levels that resist treatment in one or both parents Cholesterol deposits on the knees, elbows and buttocks High blood cholesterol levels Chest pain caused by narrow DIAGNOSIS Hypercholesterolemia is diagnosed using a number of tests including: Physical examination Blood tests Heart tests, such as stress tests
  5. INHERITANCE In great majority of cases the gene is inherited from just one parent; rarely, it is inherited from both .1n this case the risk of developing early coronary artery disease depends on the gender of the child. e If both the parents carry the mutated gene, each child has a 25 per cent of chance of inheriting both the genes containing mutation. In this case, the child will develop a severe form of coronary artery disease very early in life, perhaps while still in childhood. This form of
  6. ALLITATIONS-OF=THESTU Living family members are widely scattered and because few people keep careful written records, it is often difficult to get reliable information about deceased relatives. Recollection may be hazy or exaggerated, especially about medical histories, also adoptions, abortions, artificial insemination, and illegitimate births may go unmentioned. Another problem is the reluctance to discuss family members who are in some way abnormal. Indeed close relatives may be unaware of such individuals if they died young or were institutionalized. Stillborns and miscarriages are even likely to be remembered.
  7. METHODOLOG A survey was done among the residents of pallurity The study was conducted by carefully preparing a questionnaire containing 10 questions related to various aspects of hypercholesterolemia Both males and females were selected for the study To study the mode of inheritance of hypercholesterolemia, families were 5 randomly selected from the same population. The data obtained through discussion is
  8. SER NUMBER OF AFFECTED INDIVIDUALS MALES FEMALES FOOD HABITS NON-VEGETERIAN VEGETERIAN MAJOR CAUSE OF THE DISEASE DUE TO HERIDITY DUE TO PHYSICA INACTIVITY MODE OF TREATMENT EXERCISE DIETING MEDECINES 31 (47.7%) 34 (52.3%) Cholesterol 100% 400/0 HVIdcnaty LOLO lå*drtgty my from chietgtoe the (ICC)
  9. IGREE CHAR SELECTED FAMILY Mr. Mohanans family 1 o 3 40
  10. From the study in pallurity, high rates of female hypercholesterolemia cases were observed than in males. This may be due to urbanization and change in the lifestyle. o It is clear that in the presence of less number of heredity factors, the development of hypercholesterolemia among the studied population is purely based on number of environmental factors like physical inactivity, sedentary occupation, non-vegetarian diet etc. these factors are life induced factors.
  11. P reecanalysis-o#hypercholesterolemia shows that all the affected individuals have at least one affected parent. Males and females are affected in equal numbers. Both males and females transmit the trait. Mating of heterozygous affected with unaffected individuals produce about 1/2 affected and 1/2 unaffected offspring's. The trait does not appear in tl two unaffected parent.
  12. NCLUS Heredity induced hypercholesterolemia is lifelong and it starts from very early age. Even proper exercise, diet and medications are taken, the cholesterol levels are not lowered to a normal level completely. This is because of the presence of a defective gene. The defective gene may be due to mutation of the normal gene. Hence it is recommended that the health authorities of pallurity area should do more studies in this topic involving a majority of local community to create a better awareness among them to avert the risk of hypercholesterolemia. As a remedial measure lifestyle modifications can be taken as the first step followed by modest
  13. N/A

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