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Microencapsulation For B.Pharm Students

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Published in: MBBS Tuition | Pharma Training | Physiology
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Microencapsulation means packaging an active ingredient inside a capsule ranging in size from one micron to several from its surrounding environment until an appropriate time. Then, the material escapes through the capsule wall by various means, including rupture, dissolution, melting or diffusion. Microencapsulation is both an art and a science.

Pallab N / Kolkata

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Qualification: B.Pharma (NSHM Knowledge Campus - Kolkata (NSHMKCKolkata), Kolkata - 2018)

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  1. MICROENCAPSULATION CREATED BY PALLAB NASKAR (B.Pharm)
  2. co O O O O Definition Advantages Disadvantages Classifications Method of Preparations Evaluation Tests Applications References
  3. Definition: Microencapsulation is a process by which very tiny droplets or particles of liquid or solid material are surrounded or coated with a continuous film of polymeric materials. Particles having diameter between 3-800um are known as micro particles.
  4. Advantages: To increase of bioavailability. To alter the drug release. To improve the patient's compliance. To decrease evaporation rate of the core material. To produce a targeted drug delivery. To convert liquid to solid from.
  5. Disadvantages: O Difficult to achieve continuous and uniform film. Shelf life of hygroscopic drugs is reduced. Polymer may produce toxic effect. Costly.
  6. sslfications: Microcapsules can be classified O on three type. As follow as- e (1)Mono nuclear -Contain the shell around the core. o (2)P01y nuclear-Having many cores enclosed with in shell. e (3)Matrix type - Distributed homogeneously into the shell material. Microcapsll]c Polynucleåf 00 IllÅtriK
  7. ethod Of Preparation: ' ( 1)Physica1 Method: (a)Air suspension (b)Coacervation phase Separation (c)Pan coating (d)Spray Drying ' (2)Chemica1 Method: (a) Solvent Evaporation (b) Polymerization
  8. hod' Fine solid core materials are suspended by a vertical current of air Evaporation of the solvent The encapsulating material is deposited onto the core material Achieved the desired film thickness The encapsulated product is dried by passing the stream air Feed stuspcnsion Hot air -......> Spraying nonle _ _ Drying chamber o o Core particle Microcapsule - o o O O
  9. b ervatlon Core material phase is dispersed in the solution of coatin 01 mer Solvent of polymer is vehicle the phase Deposition of polymer solution onto the core material Deposition of liquid polymer occurs when the polymer is absorbed Microcapsule ara 'on: Otopkts POI" Sduthn 0 Memlnne 00 0 0 00 0 000 0
  10. oa In Solid particles are mixed with a dry coating material Temperature is raised The coating material melts and encloses the core particles Then is solidified by cooling Microcapsule bio MG. 12-5, Dtagmm of standard C(Mting pans.
  11. d r in Core particles are dispersed in a polymer solution Sprayed into a hot chamber Shell material are solidifies onto the core materials Solvent evaporates Microcapsule Noule Two F lid 9 Exhaust Ai Chamber Co ettion
  12. ent va Core material Dissolved Coating polymer solution With gitatio Liquid manufacture vehicle phase Heating Evaporation of polymer solvent Microencapsulation
  13. b rlza 1 Active ingredient + Polymer + Volatile solvent Addition Formation of oil in water emulsion emperature increase Solvent increase Particle formation by polymer Recovery of polymeric micro particles
  14. a uation Tests: Particle Size and Shape: Light microscopy and electron microscopy both are use to determine particle size and shape. ' Density Determination: The density of the microcapsule can be measured by using a multi volume pychnometer. 0 Isoelectric Point: The micro electrophoresis is an apparatus used to measure electro phonetic mobility. o Contact Angle: The angle of contact is measured to determine the wetting property of microcapsule. o In vitro release Studies: Release studies for microcapsules can be carried out in different pH condition like pH 1.2 and 7.4 using USP rotating basket.
  15. O O O O O O nca sulation: To improve the flow properties. Thiamine To enhances the stability. Vitamins To reduced volatility of materials. E.g =Methy1 salicylate To mask the unpleasant taste and odour. castor oil To convert liquids into solids. castor oil To reduce gastric irritation. endomethacin
  16. Conclusion: Microencapsulation means packaging an active ingredient inside a capsule ranging in size from one micron to several from its surrounding environment until an appropriate time. Then, the material escapes through the capsule wall by various means, including rupture, dissolution, melting or diffusion. Microencapsulation is both an art and a science.
  17. References: 1. Jackson L, S, Lee K, "Microencapsulationand the food industry", Lebensmitte1Wissenschaft Technologie, Retrieved 1991-02-02. 2.Au1ton ME. Pharmaceutics The science of dosage form design. NewYork: Churchill Livingstone: 1988.605-13. ' James, S. , "Encylopedia of Pharmaceutical Techonology 3rd edition,V01-, 1325-1333. Leon, L., Herbert A. L., Joseph, L. K; " The Theory And Practice Of Industrial Pharmacy" 3rd edition, 1990 Varghese Publishing House,412, 428.

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